Osmometers

The OsmoTECH HT, is the only plate-based micro-osmometer currently available to support the growing automation and high throughput needs in bioprocessing. Designed in a 96 well format this automation-friendly instrument ensures efficiency and acceleration of osmolality testing in cell line development, clone screening, early process, and formulation development. The OsmoTECH HT provides intuitive workflows and delivers unsurpassed data management and connectivity with 21 CFR Part 11 compliance features for GMP workflows.

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Description

Upstream Manufacturing Applications

CLONE SCREENING

Speed to market, boost cell longevity, increase yield and reduce production costs — Know more about your clones sooner and select the best clones earlier in the process.

CELL LINE DEVELOPMENT

Boost cell longevity and maximize cell productivity — Optimize osmolality when developing new feeds and additives in cell culture to increase cell longevity.

FORMULATION DEVELOPMENT

Accelerate formulation development and stability testing — Integrate into automated workflows providing excipient concentrations and confirm the soluble content of formulations.

Product Features

EFFORTLESSLY RUN MULTIPLE SAMPLES

The plate-loading format allows samples to be robotically pipetted into the 96-well plate. Load up to two plates onto the device for 192 tests.

AUTOMATION-FRIENDLY WORKFLOWS

Streamline efficiency and reduce hands-on operator time with seamless integration with automation workflows using Ambr®, Cedex® and Tecan®

MINIMIZE CONSUMABLES REPLACEMENT

Perform up to 1,000 tests before a consumables change is required. Uninterrupted sample testing overnight, weekend, and even holidays.

CONSERVE VITAL SAMPLES

Just a 50uL sample volume is needed for early process osmolality testing; 20 uL for STAT testing.

USER-FRIENDLY INTERFACE

An intuitive operating system and touchscreen interface provides a step-by-step guide to tests and allow users to easily get the status of tests and consumables.

ASSURE ACCURACY

Custom covers seal the plate to prevent sample evaporation to ensure repeatable and reliable results.

FLEXIBLE AND SECURE DATA MANAGEMENT

Quickly save data to a network database, USB device or web server. Automate the sample identification process and instrument control with bi-directional communication to eliminate transcription errors and save time. Easily integrate your results into a data management system and batch records with OPC-UA.

AUTOMATED SELF-CLEANING

Eliminate sample carryover and cross-contamination with automated sampling and fluid cleaning.

CUSTOMIZABLE TEMPLATES

Develop and store templates to reduce set-up time when testing large numbers of samples from bioreactors in your high-volume workflow.

SUPPORT COMPLIANCE

Data integrity features support 21 CFR part 11 compliance for ease of implementation into a GMP environment.

BACKED BY COMPREHENSIVE SUPPORT

Every Advanced Instruments osmometer is backed by a knowledgeable, experienced and responsive customer support team for complete confidence in your instrument.

Advanced-Instrument Life Science Solution

● Automation-friendly 96-well plate-based format ● Small sample volume requirement ● The gold standard freezing point depression technology ● Flexible and secure data management ● Supports 21 CFR part 11 and GMP

Sample type Aqueous-based solution
Sample volume per test 50 μL
Test time 140 seconds
Sample Capacity Multi plate
Resolution 1 mOsm/kg H2O
Range1 0-2000 mOsm/kg H2O
Accuracy2 (AI standards and reference solutions) Mean value ±3 mOsm/kg H2O from nominal value between 0 and 400 mOsm/kg H2O (1 SD) Mean value ±1% from nominal value greater than 400 to 2000 mOsm/ kg H2O (1 SD)
Within-run Repeatability2 (AI Standards and Reference Solutions) Standard deviation ≤3 mOsm/kg H2O between 0 and 400 mOsm/kg H2O Coefficient of variation ≤1% greater than 400 to 2000 mOsm/kg H2O
Operating conditions Temperature: 18 °C to 35 °C (64 °F to 95 °F) Humidity: 5 to 80% relative humidity (non-condensing)
Supported Languages English, Simplified Chinese, French, German, Italian, Japanese, Korean, Portuguese, Russian, Spanish, Turkish
Storage temperature -20°C to +45°C (-4°F to +113°F)
Electrical voltage 100 to 240 VAC (50/60 Hz)
Power consumption 60 Watts
Dimensions (D x W x H) 48.9 cm D x 62.87 cm W x 68.58 cm H (19.25” D X 24.75” W X 27 H”)
Net weight 59.7 kg (131.6 lbs.)
Shipping weight 111.9 kg (246.6 lbs.)
Warranty One-year limited warranty on workmanship and parts
  1. Advanced Instruments completes testing from 0 mOsm/kg sample to 2000 mOsm/kg sample during in-house linearity testing.
  2. Performance at reference conditions: 20 °C to 25 °C (68 °F to 77 °F); 30 to 60% relative humidity.

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